Optical-WiMAX Hybrid Networks

The emergence of bandwidth-intensive Internet services, such ascircuit-quality voice transfer and interactive video gaming, createa high demand for a very qualified next-generation access network.In addition to high bandwidth, these future access networks shouldalso provide improved network availability, flexibility, mobility,reliability, failure protection, quality of service (QoS) supportand cost-effective access. The integration between optical networksand Worldwide Interoperability for Microwave Access (WiMAX) is apromising solution for future access networks. Accordingly, a fewdifferent architectures and MAC protocol components have recentlybeen proposed for the integration between the Ethernet PassiveOptical Network (EPON) and WiMAX. However, the proposedarchitectures contain several drawbacks. Moreover, the EPON-WiMAXhybrid does not yet contain a comprehensive Medium Access Control(MAC) protocol and a mechanism for Quality of Service (QoS) support.Finally, this work introduces the Resilient Packet Ring (RPR)standard, which aims to build high-performance metro edge and metrocore ring networks that interconnect multiple access networks. Theobjective of this thesis is to examine the integration of opticalstandards, such as RPR and EPON, with the WiMAX standard.Subsequently, this integration will be applied to the areas ofarchitecture and MAC Protocol as a promising solution for not onlyaccess networks but also for metro networks.The first part of the thesis examines the EPON-WiMAX integration asa solution for the access network. Specifically, the proposedsolution includes new EPON-WiMAX hybrid network architectures thatare suitable for both urban and rural environment requirements, andit also introduces a joint MAC protocol for these architectures. Theproposed architectures are reliable and provide extended networkcoverage; in particular, reliability is achieved by applying aprotection scheme to the most critical portion of the EPON part ofthe architecture. Additionally, the network coverage of thearchitecture is extended by inserting an intermediate networkbetween the front end and the backhaul network of the traditionalEPON-WiMAX architecture. Subsequently, we propose a comprehensivejoint MAC protocol for the proposed EPON-WiMAX architecture; thisprotocol provides a per-stream quality-of-service guarantee andimproves the network utilization. Also, the proposed joint MACprotocol includes an admission controller, a scheduler and abandwidth allocator.While the first part of the thesis strives to improve the hybridnetwork reliability through protection in the EPON part and extendthe network coverage through innovative methods, the second partattempts to maintain and enhance these objectives by adding areliable technology to the integrated network. Specifically, thissection examines the way in which the RPR network can be integratedwith the proposed EPON-WiMAX architecture to form an RPR-EPON-WiMAXhybrid network, which can be a solution for both access and metronetworks. The proposed architecture is reliable due to thedependability of the RPR standard and the protection mechanismemployed in the EPON network. Moreover, the architecture contains ahigh fault tolerance against node and connection failure. In thesecond part, the joint MAC protocol for the RPR-EPON-WiMAX hybridnetwork includes a multi-level dynamic bandwidth allocationalgorithm, a distributed admission control, a scheduler, and arouting algorithm. This MAC protocol aims to maximize the advantagesof the proposed architecture by distributing its functionalitiesover the parts of the architecture and jointly executing the partsof the MAC protocol

PREPARATION AND EVALUATION OF METRONIDAZOLE SUSTAINED RELEASE FLOATING TABLETS

Objective: The objective of the present study is the preparation of metronidazole (MZ) floating tablets that are designed to retain in the stomach for a long time for better eradication of Helicobacter Pylori (H. pylori), a main cause of peptic ulcer disease. Methods: Synthetic and natural polymers were studied for their floating potential in the presence of sodium bicarbonate, namely: hydroxypropyl methylcellulose (HPMC), carbopol 974P, sodium alginate{low and medium viscosity (LV & MV) grades}, locust gum and guar gum. Hardness, floating ability, release profiles and kinetics as well as DSC / FT-IR were studied. Results: Results of both DSC and FT-IR spectroscopy revealed that there was no interaction between the drug and any of the proposed polymers. Carbopol 974P based tablets showed an unacceptable floating lag time (2 h) and did not maintain good tablet integrity. All other formulas were able to float after few seconds and showed buoyancy for more than 24 h. Meanwhile, sustained profiles of MZ release were obtained. After 6 h the amount of MZ released were: 75.11 %, 61.26 %, 54.56 %, 54.25 % and 43.42 % from sodium alginate-LV, HPMC-K4M, guar gum, locust gum and sodium alginate-MV based tablets, respectively. Kinetically, among the 5 assessed models, the release pattern of MZ from the tablets fitted best to Zero order and Hixson & Crowell Cube-Root models. Conclusion: These stomach targeted dosage forms could maintain the minimum inhibitory concentration for sufficient time to allow for local eradication and thereby achieve better efficiency of therapy with improved patient compliance, reduced costs and minimized side effects caused by immediate release dosage forms

Cyber Physical Energy Systems Modules for Power Sharing Controllers in Inverter Based Microgrids

The Microgrids (MGs) are an effective way to deal with the smart grid challenges, including service continuity in the event of a grid interruption, and renewable energy integration. The MGs are compounded by multiple distributed generators (DGs), and the main control goals are load demand sharing and voltage and frequency stability. Important research has been reported to cope with the implementation challenges of the MGs including the power sharing control problem, where the use of cybernetic components such as virtual components, and communication systems is a common characteristic. The use of these cybernetic components to control complex physical systems generates new modeling challenges in order to achieve an adequate balance between complexity and accuracy in the MG model. The standardization problem of the cyber-physical MG models is addressed in this work, using a cyber-physical energy systems (CPES) modeling methodology to build integrated modules, and define the communication architectures that each power sharing control strategy requires in an AC-MG. Based on these modules, the control designer can identify the signals and components that eventually require a time delay analysis, communication requirements evaluation, and cyber-attacks’ prevention strategies. Similarly, the modules of each strategy allow for analyzing the potential advantages and drawbacks of each power sharing control technique from a cyber physical perspective

The proton radius puzzle

High-precision measurements of the proton radius from laser spectroscopy of muonic hydrogen demonstrated up to six standard deviations smaller values than obtained from electron-proton scattering and hydrogen spectroscopy. The status of this discrepancy, which is known as the proton radius puzzle will be discussed in this paper, complemented with the new insights obtained from spectroscopy of muonic deuterium.Comment: Moriond 2017 conference, 8 pages, 4 figure

Laser excitation of the 1s-hyperfine transition in muonic hydrogen

The CREMA collaboration is pursuing a measurement of the ground-state hyperfine splitting (HFS) in muonic hydrogen ($\mu$p) with 1 ppm accuracy by means of pulsed laser spectroscopy to determine the two-photon-exchange contribution with $2\times10^{-4}$ relative accuracy. In the proposed experiment, the $\mu$p atom undergoes a laser excitation from the singlet hyperfine state to the triplet hyperfine state, {then} is quenched back to the singlet state by an inelastic collision with a H$_2$ molecule. The resulting increase of kinetic energy after the collisional deexcitation is used as a signature of a successful laser transition between hyperfine states. In this paper, we calculate the combined probability that a $\mu$p atom initially in the singlet hyperfine state undergoes a laser excitation to the triplet state followed by a collisional-induced deexcitation back to the singlet state. This combined probability has been computed using the optical Bloch equations including the inelastic and elastic collisions. Omitting the decoherence effects caused by {the laser bandwidth and }collisions would overestimate the transition probability by more than a factor of two in the experimental conditions. Moreover, we also account for Doppler effects and provide the matrix element, the saturation fluence, the elastic and inelastic collision rates for the singlet and triplet states, and the resonance linewidth. This calculation thus quantifies one of the key unknowns of the HFS experiment, leading to a precise definition of the requirements for the laser system and to an optimization of the hydrogen gas target where $\mu$p is formed and the laser spectroscopy will occur.Comment: 21 pages, 4 figure

An argument against the focus on Community Resilience in Public Health

Background - It has been suggested that Public Health professionals focus on community resilience in tackling chronic problems, such as poverty and deprivation; is this approach useful? Discussion - Resilience is always i) of something ii) to something iii) to an endpoint, as in i) a rubber ball, ii) to a blunt force, iii) to its original shape. “Community resilience” might be: of a neighbourhood, to a flu pandemic, with the endpoint, to return to normality. In these two examples, the endpoint is as-you-were. This is unsuitable for some examples of resilience. A child that is resilient to an abusive upbringing has an endpoint of living a happy life despite that upbringing: this is an as-you-should-be endpoint. Similarly, a chronically deprived community cannot have the endpoint of returning to chronic deprivation: so what is its endpoint? Roughly, it is an as-you-should-be endpoint: to provide an environment for inhabitants to live well. Thus resilient communities will be those that do this in the face of challenges. How can they be identified? One method uses statistical outliers, neighbourhoods that do better than would be expected on a range of outcomes given a range of stressors. This method tells us that a neighbourhood is resilient but not why it is. In response, a number of researchers have attributed characteristics to resilient communities; however, these generally fail to distinguish characteristics of a good community from those of a resilient one. Making this distinction is difficult and we have not seen it successfully done; more importantly, it is arguably unnecessary. There already exist approaches in Public Health to assessing and developing communities faced with chronic problems, typically tied to notions such as Social Capital. Communityresilience to chronic problems, if it makes sense at all, is likely to be a property that emerges from the various assets in a community such as human capital, built capital and natural capital. Summary - Public Health professionals working with deprived neighbourhoods would be better to focus on what neighbourhoods have or could develop as social capital for living well, rather than on the vague and tangential notion of community resilience.</p

The next generation of laser spectroscopy experiments using light muonic atoms

Precision spectroscopy of light muonic atoms provides unique information about the atomic and nuclear structure of these systems and thus represents a way to access fundamental interactions, properties and constants. One application comprises the determination of absolute nuclear charge radii with unprecedented accuracy from measurements of the 2S$\,$-$\,$2P Lamb shift. Here, we review recent results of nuclear charge radii extracted from muonic hydrogen and helium spectroscopy and present experiment proposals to access light muonic atoms with $Z \geq 3$. In addition, our approaches towards a precise measurement of the Zemach radii in muonic hydrogen ($\mu$p) and helium ($\mu$$^{3}$He$^{+}$) are discussed. These results will provide new tests of bound-state quantum-electrodynamics in hydrogen-like systems and can be used as benchmarks for nuclear structure theories.Comment: 17 pages, 8 figure

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p&lt;0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p&lt;0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised